Abstract: Abstract: Huanghuai region is characterized by high temperature and plenty of heavy precipitation during the jointing-booting stage of rice, which may result in frequent occurrence of waterlogging and hot damage on rice field. Waterlogging and high temperature may interactively impact on rice growth and yield. This study aimed to investigate the response of rice growth and yield to the interaction of waterlogging and high temperature stress. In order to make a deep understanding on the effects of high temperature and waterlogging stress on rice (Oryza sativa L., Huodao 008) morphological characters and yield at jointing stage, 6 treatments were set up as follows: high temperature stress (T1), high temperature × light waterlogging stress (water depth of 10 cm, T2) , high temperature × heavy waterlogging stress (water depth of 15 cm, T3), light waterlogging stress (T4), heavy waterlogging stress (T5), as well as a regular irrigation with shallow water (water depth of 0-5 cm) except for yellow maturity (CK). After stress treatment, the rice plant height, leaf area, shoot dry matter and yield factors were observed. Logistic equation and Gaussian Function were used to fit curves. The change trend of rice morphological characters and yield factors under interaction of high temperature and waterlogging stress were analyzed. The results showed that: 1) Compared with CK, rice plant height under high temperature stress (T1) and heavy waterlogging (T5) treatments was decreased by 5.63 and 5.96 cm at the heading stage, respectively. The interaction stress of high temperature and waterlogging had a weak inhibitory effect on rice growth compared to T1 or T5. 2)With advance of the growth period, rice leaf area showed a decrease trend after a first increase and the leaf area reached the maximum at the late jointing stage. The leaf area under the interaction of high temperature and waterlogging stress (T2, T3) was increased. Dry matter accumulation of the above-ground part of rice under high temperature and heavy waterlogging stress (T3) was increased compared to CK, but it was reduced under only high temperature stress (T1). 3) Except for light waterlogging stress (T4), the rice yield in all stress treatments were significantly reduced. Compared with CK, the rice yield under the interaction of high temperature and light waterlogging stress (T2) and high temperature and heavy waterlogging stress (T3) were significantly decreased by 44.16% and 22.29%, respectively, which was due to the decrease of filled grain rate. Through the analysis of two factors interaction, temperature stress and the interaction stress of water and temperature had significant influence on the yield factors of rice, but the water stress only had significant influence on the spikelet length, the number of effective panicles and the yield. In sum, rice yield were reduced under heavy waterlogging, high temperature and interaction of high temperature and waterlogging stress, but interaction of high temperature and heavy waterlogging stress can effectively weaken rice yield reduction.