Abstract: Abstract: In recent years, the consumption of livestock and poultry products has increased rapidly in China, which has accelerated the development of livestock and poultry industry. At the same time, it also brings the problem of waste pollution. The direct discharge of untreated or improperly treated animal manure waste water will cause pollution to the soil, air and water, and be harmful to livestock's and poultry's and human's health. Seriphidium transiliense is a semi-shrub of the Compositae Seriphidium. Its seeds can secrete mucilaginous in contact with water. Mucilaginous substances are harmless to the human body and are cost-effective and biodegradable. It can be used as a potentially environment friendly flocculant because it can be used to treat various kinds of sewage. The purpose of this study was to preliminarily explore the extraction process of seed mucus from Seriphidium transiliense and the effect of mucilaginous as flocculant on the treatment of common animal husbandry fecal wastewater. The flocculation rate and COD were taken as the determination index. The optimum conditions were obtained through the influence of different pH value (6.0, 6.5, 7.0, 7.5, 8.0, 8.5) and the different leaves of dosage flocculant (10, 20, 30, 40, 50 mL/g) on the flocculation effect of livestock and poultry waste water. In this study, three factors (extraction time, liquid-solid ratio and extraction temperature) effecting the rate of mucilaginous extraction were studied by screening clean seed of Seriphidium transiliense as material for mucilaginous extraction. The results of response surface method showed that the highest extraction effeciency of seed mucilaginous of Seriphidium transiliense was 16.76%, the extraction time was 3 h, liquid-solid ratio was 60:1, and the extraction temperature was 64℃. When the dosage of mucilaginous was 50 mg/L, the flocculation rate was 28%, the COD removal rate was 32.7%, pH value was 6, the flocculation rate was 46%, and the COD removal rate was 44.6%. The combination of aluminum had a remarkable effection on flocculation rate. The maximum flocculation efficiency and COD removal rate were 72.3% and 61.3%, respectively. During the treatment of pig feces, When the dosage of mucilaginous was 20 mg/L, the flocculation rate was 30.9%, the COD removal rate was 32.7%, pH value was 7, the flocculation rate was 29.3%, and the COD removal rate was 50%. The combination of aluminum had a remarkable effection on flocculation rate. The maximum flocculation efficiency and COD removal rate were 62.6% and 68.3%, respectively. Therefore, the flocculation rate and COD removal rate also increased with the increase of mucilaginous dosage during the treatment of cattle and pig manure. The combined use of alum and mucilaginous could significantly improve the flocculation rate and COD removal rate. When the addition of mucus was 50 mg/L and the pH value was 6, used together with alum, the flocculation and COD removal rates of bovine feces were 72.3% and 61.3%. When the addition of mucilaginous was 20 mg/L and the pH value was 7, used together with alum, the flocculation and COD removal rates of bovine feces were 62.6% and 68.3%, respectively. This study provides a reference for the development and application of Seriphidium transiliense germplasm resources in the sewage treatment of livestock and poultry feces waste water.