Abstract: In recent years, with the rapid development of the poultry industry in China, it has brought enormous challenges to the ecological environment. The reduction, recycling and innocuous treatment of these organic solid wastes can be achieved by aerobic composting. The vertical reactor has a simple structure, effectively shortens the compost reaction time and improves the composting reaction environment. Therefore, the aerobic compost reactor has good practical value. However, due to the gravity accumulation of the material, the reactor has some problems, such as compacted material, poor ventilation, high ventilation resistance, and difficulty in homogenizing the product. In order to solve these problems, spiral-belt-spiral-impeller aerobic compost bioreactor was designed with real-time monitoring of insulation, temperature and oxygen content. This reactor has a volume of 100 L. Computational fluid dynamics method was used to analyze the flow field within the reactor. The 3D solid modeling of the internal flow field model in the reactor was completed by Soildworks modeling, and the MRF(multiple reference frame) method was used to deal with the interaction between the stationary reactor inner wall and the moving stirring blade. The analysis of the velocity field distribution and velocity vector on the y=0 section demonstrated that the reactor had good axial flow through the internal velocity distribution. The performance of the reactor was studied in aerobic composting test. The raw materials for composting were cow manures, wheat straw and mushroom residues, and the total reaction time was 24 days. The reaction was evaluated by measuring the temperature, oxygen concentration, total carbon, total nitrogen, C/N, total phosphorus, total potassium, germination index, total heavy metals and sensory indicators in the upper, middle and lower layers of the reactor. During the composting reaction process, the performance of aerobic composting test showed that the upper, middle and lower temperatures above 50℃ were 7.3, 6.8, 5.5 days, respectively, and the temperature first increased and then decreased. The oxygen concentration during the reaction was higher than 8%. The lowest value appeared around the fourth day. In the aerobic composting process, the moisture content and total carbon content showed a downward trend, while the total nitrogen content, total phosphorus content and total potassium content showed an upward trend. The moisture content gradually decreased from 65.76% to 42.5%, 42.1% and 41.7%, the carbon content decreased from 39.3% to 33.8%, 33.6% and 33.5%, the total nitrogen content increased from 1.37% to 2.01%, 2.01% and 2.03%, the total phosphorus content increased from 0.88% to 1.04%, 1.03% and 1.04%, the total potassium content increased from 1.57% to 1.74%, 1.75% and 1.73%, which were related to the law of microbial activity in the reactor. After composting, it has no obvious foul smell compared with the initial heap. The C/N of each layer was between 15 and 20, and the germination index was greater than 88%. The heavy metals such as Cu, Zn, Cr, Pb and Cd met the national standards. Therefore, the reactor could achieve harmless and uniform compost.