Abstract: Abstract: In the context of global climate change, most previous studies focused on the interannual change trend of vegetation and its response to precipitation and temperature, but ignore the influence of radiation factors. The response of different vegetation types to seasonal multi-climate factors (precipitation, temperature, and radiation) was explored and the impact of human activities on vegetation was quantified in this study. It is of great significance to ecological environment protection in China. In this study, the spatiotemporal variations in the Normalized Difference Vegetation Index (NDVI) and climate change were investigated using the AVHRR NDVI3g data, land use data and gridded climate data, A multiple linear regression model was then used to determine the driving factors of vegetation change using residual analysis at the regional and national scales from 1982 to 2015. The results show that there was outstanding regional spatial characteristic of vegetation changes with a decreasing trend from the southeast to northwest China, where the annual rate of change ranged from -0.016/a to 0.029/a. An increasing trend was found in the temperature and solar radiation, whereas, the precipitation showed a downward trend in most regions. According to the Hurst index, 80.62% of the vegetation presented a continuous and stable change, while the grasslands and woodland tended to be unstable and vulnerable to climate change and human activities. The NDVIs of Junggar Basin, Qinghai-Tibet Plateau, and Xilin Gol League of Inner Mongolia were negatively correlated with the air temperature and solar radiation, whereas, the NDVIs of Yunnan-Guizhou Plateau, southern Loess Plateau, and Sichuan Basin were positively correlated. The residual analysis showed that the drought resulted in the vegetation degradation in the arid areas, such as Xinjiang Junggar Basin and central Inner Mongolia, while the increase of temperature and radiation was the main driver for the vegetation improvement in the eastern coastal plain, the southern Loess Plateau, Sichuan Basin, and the southwestern Yunnan-Guizhou Plateau. Since the beginning of the 21st century, human activities were gradually strengthened, including soil and water conservation, the conversion of farmland to forest on the Loess Plateau, the desert control in Alxa, as well as the construction of coastal city clusters and northeast industrial bases. Thus, the vegetation improvement was identified in the Alxa Plateau of Inner Mongolia, the central and northern Loess Plateau, and most parts of South China, whereas, the vegetation degradation was detected in the Greater and Lesser Khingan Mountains, the eastern regions of the Changbai Mountains and the Yangtze River Delta. Among them, the national projects of ecological protection were attributed to the significant improvement of vegetation conditions. Consequently, the monitoring of vegetation degradation can provide a theoretical basis for the implementation of ecological restoration and the construction of ecological civilization in the future. The finding can greatly contribute to regional green and sustainable development.