Abstract: Sea areas can often include the continental shelf, exclusive economic zones, and territorial seawaters. Among them, the deep and far sea space is the connecting and transitional area between territorial seas and the oceans, which is situated in the continental shelf and exclusive economic zone. It is highly valuable in biological and natural resources from a strategic standpoint. Therefore, the deep and far sea space can be explored to promote the ecological environment and spatial utilization in nearshore seas. Fresh space can also provide to reduce the various constraints on resources in the blue economy. In this study, the deep-sea spatial patterns were determined with multiple factors, dimensions, and long-term time series. A rapid and accurate recognition was constructed using multi-source data spatialization. The "three types of spaces" were laid out with eastern Guangdong as the empirical object. The spatiotemporal characteristics of various sea use activities were explored to establish spatial use management. The results show that: 1) Deep and far sea space was classified into the protection, preservation, and utilization spaces, corresponding to the protection, preservation, as well as development and utilization functions, respectively. The spatial identification relationship of multi-source data was examined and quantified, such as ecology, resources, and environment. The spatial selection of various targets was implemented using spatial stacking and two-dimensional quadrant methods. 2) The protected space in the eastern Guangdong Sea area was located mainly in the northwest of the study area, accounting for 46% of the total space; The proportion of preserved space area unsuitable for development and construction was 43%; Shallow seas below the 200m isobath in the southern Taiwan Strait (as much as 11% of the total area) were the appropriate utilization space for offshore wind power installation and marine fisheries. 3) A series of analyses was performed on the spatiotemporal trajectory and conflict relationship of sea use activities, combining mobility, vertical depths, and time scales with spatial occupancy range to characterize the features of sea use activities; Some activities shared the strong spatial attributes, such as wind power development and mineral resource exploration. There were much stronger time attributes of navigation, habitat protection, and cable pipelines. The finding can also provide a strong reference for the decision-making on the national spatial planning in the deep and far sea space for the marine spatial layout.