Abstract: Abstract: Along with the promotion of urban-rural integration, agricultural scientific parks calls for spatial integrative distributions of functions such as agricultural production services, scientific research, exhibition, science popularize training and tourism. Evaluation of land sustainability classifies sustainability of functions including production, living, relaxing, and ecological security, projects development potential of land with a certain function by current situation, and thus contributes to optimal allocation and rational distribution of land. This study takes an example of Baima Teaching and Research Base of Nanjing Agricultural University with GIS and RS data based on existing models, incorporating water ecological security factors as well as factors such as elevation, slope, noise and land-use into land sustainability evaluation. By quantitative spatial modeling and evaluation, we can give an integrative evaluation of land sustainability of different planning and determines the Plan Six as the best planning. Specific steps are as follows: (1) Determine natural and environmental factors as the main factor impacting the function layout, such as living function, public services, agricultural production, exhibition function and teaching function; (2) Roads and land use data can be obtained through the vectorization of remote sensing data, and then create DEM data through terrain data, thus generated slope combined with ArcGIS terrain analysis on the one hand; get collection waterline according hydrological model on the other hand; (3) Computing the weight value of five kinds of factors of five function layout by combining Analytic Hierarchy Process and expert opinion; (4) Mapping the land suitability of different function layout through overlay analysis by ArcGIS, then analyzing the distribution; (5) According to the results of land suitability analysis, weighted evaluation the total land suitability of different planning scheme, then determines the Plan Six as the highest land suitability; (6) Finally, taking the environmental pollution of agricultural production into account, Plan Six isolated the agricultural production area and living function area; and secondly; Plan Six fully consider the effect of ecological and water landscape of Hanziba Reservoir in the eastern part of the study area, so that the layout of teaching, living and public facilities can make full use of the original soil and water natural resources. Based on the analysis above, determining the Plan Six as the best planning and put it into effect. The conclusions are withdrawn as follow: (1) By incorporating indicators of ecological security pattern of small watershed into the evaluation indicator system, the evaluation of land sustainability become more scientific. (2) Compared with traditional fixed planning scheme in college plans, our model evaluated Six Planning Schemes based on land sustainability. Alternatives analysis and quantitative study combined to reach a more reasonable and applicable spatial distribution scheme. (3) This article integrated the rational requirements of spatial distribution into planning evaluation, thus laid a foundation for qualitative and quantitative modeling of agricultural teaching and research bases. Scientific and practicability of evaluation results can be concluded as results show that land sustainability evaluation with water ecological security makes an effective evaluation and comparison of different planning for the determination of the best planning and the functional distribution of land. This study demonstrated the feasibility of our method, offered a new approach for the evaluation of agricultural scientific park planning and provided basis and decision support for comprehensive urban-rural land planning.