Abstract: Bovine colostrum was freeze dried according to the method of quadratic rotation orthogonal experiment. By the experimental data, the mathematics models of energy consumption and productivity, with the freeze drying chamber pressure, colostrum thickness and concentration were established and the effects of the three parameters on the objectives were given. Also, the minimum energy consumption under the restrict conditions of high productivity was conducted. The results were as follows: pressure 54.5 Pa , thickness 10.02 mm , concent ration 36.73%.