Abstract: Tocopherol has very high physiological activity. Soybean deodorizer distillate contains plentiful natural tocopherol. For extracting tocopherol from soybean deodorizer distillate, solubility of α-tocopherol in supercritical CO₂ was measured. The solubility data were correlated respectively by Radial Basis Function(RBF) neural networks model and Chrastil model. Relative error of Chrastil model is 25.36%. By means of learning and training on RBF neural networks model, the average error of training set is 0.32% and that of testing set is 6.48%. RBF neural networks model is better comparatively.