Abstract: In order to guide people to select optimal treatment patterns which can achieve the best economic benefit according to different grain-land areas and different technical economy levels, the grain loss rate, operating efficiency, ratio of benefit to cost, results of increasing grain output and decreasing grain loss, cost saving and critical economic value of three typical grain post-harvest treatment patterns in Zhejiang Province were analyzed by using GAMS simulation. The adjusted treatment pattern fit for this region was provided. And this treatment can improve the grain post-harvest processing and make the benefit best.