Abstract: According to the theory of circular economy and sustainable development, and based on the principle of maximizing the utilization of resources and energy, a comprehensive route has been put foreword to control sewage pollution on swine farm, combining solid-liquid separator with anaerobic fermentation. The practice of swine sewage treatment on large-scale farm in Nanping Daheng Agroecological Farm, showed that pollution problem in animal husbandry industry could be solved by such a route. The out-let wastewater indexes for COD_Cr, BOD₅, SS and NH⁺₄-N, reached 367 mg/L, 132 mg/L, 169 mg/L, 76 mg/L, respectively, which meet the Intergratel Pollutant Discharge Standard according to "The drainage standard for sewage from livestock and poultry production". The project was operated stably and remarkable benefits in economy and ecology were obtained.