Abstract: In order to resolve the clogging problem of emitter from structure design and aiming at various kinds of small labyrinth channels of the drip irrigation emitters, the Computational Fluid Dynamics (CFD) was used to conduct the numerical simulation and visually reveal the flow behaviors in the labyrinth channels of emitters. The velocity field was measured by Laser Doppler Velocimeter(LDV) in hydrodynamic similarity experiment to verify the computational results. On this basis, the anti-clogging mechanism was analyzed. A "main-route anti-clogging design" method was proposed to optimize the structure in the stagnant areas in order to enhance anti-clogging performance of emitter channels. And it was verified through anti-clogging experiment.