Abstract: The influence of drying parameters of vacuum drying on productivity and quality of Pteridium Aquilinum drying was investigated, and the impact of drying temperature, vacuum degree and material thickness on vitamin C content was studied by nonlinear regressional orthogonal design. Using single and double factor analysis method, the relation between experimental criteria and drying parameters was established, and the influence order of the parameters was determined. Experimental results show that vacuum degree have greatest influence on the vitamin C content of Pteridium Aquilinum, then the drying temperature, least the material thickness. The optimum drying parameters for obtaining higher vitamin C content product are 58.7℃, 0.072 MPa and 12 mm material thickness.