Abstract: Xinjiang region is an expansive Region and climate is very different among areas. It is very important for water saving irrigation planning to make the accurate estimation of reference evapotranspiration for every region. ET₀ was computed by six methods with data from four typical weather stations of Xinjiang. As Penman-Monteith method is taken as the standard, the comparison is taken and the results are as follows. 1948Penman is a better method for every climatic area than FAO-24 Penman and FAO-24 Radiation. If climatic data are insufficient, both Hargreaves method for any region and Priestley-Taylor for humid may provide reliable ET₀ estimates. Meanwhile the relationship between the ET₀ value computed by P-M method and evaporation is analyzed and that can provide a reference for estimating ET₀ using evaporation data for Xinjiang region.