溶剂法提取丹皮酚的工艺优化

Optimization of the technology for extracting paeonol from cortex moutan with solvents

摘要: 以筛选从丹皮中提取丹皮酚的理想溶剂及最佳工艺参数为目的，通过高效液相色谱测定研究了不同溶剂提取丹皮酚的效果，通过正交试验设计研究了四氯化碳提取丹皮酚的最佳条件。结果表明，溶剂法提取丹皮中丹皮酚的理想溶剂为四氯化碳。以牡丹根皮为材料，以四氯化碳为溶剂，最佳工艺参数为料液比1∶25(w/v)、丹皮粒径0.90 mm、浸提时间6h。按此最佳工艺参数，一次提取，丹皮酚提取量11.428 g/kg，占提取总量的89.857%；两次提取合计丹皮酚提取量12.30 g/kg，占提取总量的96.79%。

Abstract: In order to select the best solvent and optimum technology parameters for extracting paeonol from cortex moutan, the effects of differentsolvents on extracting paeonol were investigated by HPLC and orthogonal experiment.Results show that the best solvent is carbon tetrachloride(CCl₄), and the optimum technology parameters are as follows: the ratio of solid to liquid is 1∶25(w/v), the diameter of granule of cortex moutan is 0.90 mm, and theextracting time is 6 h. Using the optimum parameter set, the quantity of paeonol is 11.428 g/kg from once extraction of the first time, being 89.857% of the total quantity of extracted paeonol, and 12.30 g/kg, be 96.79% paeonol obtained from twice extractions.