Abstract: In order to realize the transformation of agricultural residues into the industrial product(fuel methanol), biomass energy is used efficiently. The reaction kinetics of methanol synthesis for the cornstalk syngas has been studied in a tubular-flow integral and isothermal reactor. A domestic Cu-based catalyst C301 (Particle size: 0.175 mm×0.147 mm) was used. The temperature ranges from 220℃ to 270℃ , the pressure is 5 MPa and the mass space velocity is 15532.67～26343.47 NL/(kgcat?h). The Langmuir-Hinshelwood type intrinsic kinetic model was used. The improved Gauss-Newton method was used to confirm the parameters of the kinetic model. The statistic test and residual error distribution show that L-H type intrinsic kinetic model can suit for the reaction conditions and can be used to design the methanol synthesis reactor and the industrial test of methanol production from biomass (corn stover) gas.