Abstract: To solve the problem of high content of bedload in Yellow River’s water for agricultural drip irrigation, the dish separator and FXJ-150-I hydrocyclone was connected in series to seperat silt from Yellow River’s water. The influences of the series connection seperation equipment on the overflow flux and sediments half-content diameter D50 were studied by orthogonal test, range analysis and variance analysis. The results show that the important order of the parameters influencing the overflow flux is as follows:inlet pressure, underflow port diameter and drum rotation speed. As for the D50, the order is inlet pressure, drum rotation speed and underflow port diameter. Considering the influence extent of tested factors on the overflow flux and sediments half-content diameter D50 and the separation efficiency, the parameters of the equipment are optimized as follows: inlet pressure 0.06 MPa, underflow port diameter12 mm, drum rotation speed 3500 r/min.