Abstract: Based on the dynamic composting process of wastewater sludge from China Resources (Wuhan) Breweries Co., Ltd., the dynamics of different operational and evaluating indices, such as temperature, moisture content, pH, humic acid, total organic carbon, total nitrogen, water-soluble organic carbon and germination index (GI) and so on, during the treatment process were discussed. The results indicated that cottonseed cake used as compost amendment of brewery sludge. Brewery sludge and cottonseed cake mixed in accordance with the ratio of 4:1 (add a small amount of urea, adjust C/N ratio of 30:1, 60% moisture content). 50 kg was a unit which was packed into a bag for sealing and micro-aerobic composting fermentation. The product of composting was mature after 20 days, which was loose and odorless. Almost mature output could meet the land application control standard of MSS and the class A standard of US EPA. The study provides the technical basis for new process of establishing rapid and high-efficient processing Brewery sludge.