Abstract: In order to protect and utilize groundwater resource, the groundwater special vulnerability zoning model for the reclaimed water irrigation district was established which was based on DRASTIC model. The six factors were considered which were the groundwater depth, rainfall recharge, surface soil media type, unsaturated zone lithology, hydraulic conductivity of aquifer and land use type in this model according to the actual conditions of study area and influencing factors of groundwater vulnerability. By the GIS technology and Nemerow index, the groundwater comprehensive pollution index distributing map was maken, and the verification method and classification standards of the groundwater vulnerability zoning were explored. The results indicated that there was a significant regression relationship between groundwater comprehensive pollution index and groundwater vulnerability in research area (R2=0.9591). The groundwater vulnerability assessment result by the DRASTIC model was reasonable. This result can be used for the planning of the groundwater protection and utilization in reclaimed water irrigation districts.