Abstract: Currently, the chicken disease diagnosis system based on desk-top computers has displayed timely inconvenience and poor coverage in operation. To meet the demands of medium or small-scale poultry farms and grass-root veterinarians, a chicken disease diagnosis and health management system based on windows mobile 5.0 working under Net 2005 and SQL Sever 2005 CE was developed. Object-oriented knowledge bases were established and credibility factors (CF) were also introduced in the inference mechanism. The system could diagnose more than 70 common chicken diseases and provide suggestions on appropriate veterinary drugs and treatment with 3 options: obvious symptoms, suspect diseases and multi-symptom combinations. The system performance test showed that diagnostic accuracy of the assistant system based on smart mobile phones was to 88.3%. The windows mobile system was convenient to operate and easy to put into use. With the integration of TD-SCMA and Internet, the system can definitely foresee a wide application in the countryside because it can be kept up-dated in time and improve its accuracy in diagnosis.