Abstract: Emitter with tooth-labyrinth paths was main research subject. The distribution law of sand content and hydraulic performance of emitter were analyzed by CFD (computational fluid dynamics) two-phase simulation technology firstly. The optimal design method of labyrinth paths was proposed that the lesser isoline of sand content was regarded as the borderline of labyrinth paths. According to the results of two-phase CFD simulation on the optimal structure, the sand content of labyrinth paths by optimized was more uniform than before, the phenomenon of a large number of solid particles concentrated on the surface near the entrance and exit of labyrinth paths was basically eliminated, the anti-clogging performance of emitter was significantly improved. Secondly, based on optimized structure, a standardization optimized structure was designed, the prototype structure emitters and the standardization optimized emitters were produced by mould. Finally, hydraulic performance of tooth-labyrinth paths and distribution of sand were tested by combined CFD simulation and period clogging experiment. Accuracy of sand distribution with CFD simulation was tested with short period clogging experiment. The results showed that the emitter by anti-clogging optimal design with the lesser isoline of sand content as the borderline of labyrinth paths maintained the previous excellent hydraulic performance, its anti-clogging performance was significantly improved from prototype structure，the life was twice as prototype structure.