Abstract: In order to solve the problems of the existing automatic measuring system for grain storage condition such as single function, low performance-price ratio, short of flexibility, weak data transmission ability and so on, this paper analyzed the limitations of the existing automatic measuring system for grain storage condition, and the new type multi-parameter automatic measuring system for grain storage condition based on wireless sensor networks was designed, then the architecture, hardware and software design approach of the proposed system were presented in detail. The designed system could implement the real-time, multi-point detection of multiple parameters related to grain storage condition, including ambient temperature inside and outside the granary, ambient humidity inside and outside the granary, several harmful gas concentrations, grain storage temperature, moisture content and pests, and the measured data could be sent to the remote monitoring center through a reliable wireless communication network. The preliminary experimental results proved the rationality and practicability of this system. This research can provide references for the application of wireless sensor networks in the grain depot.