Abstract: In order to improve the performance of deep-well centrifugal pumps, a three dimensional surface type guide vane and a cylindrical guide vane were designed. The two-stage deep-well centrifugal pump equipping with different guide vanes were simulated in FLUENT 6.2 code based on the standard k-ε turbulence model. The pump performance and the static pressure distribution in the guide vanes were analyzed and compared. The results indicated that the three-dimensional surface type guide vane had smaller hydraulic loss and higher pressure conversion capacity. Meanwhile, the pump efficiency and single-stage head of the three-dimensional surface type guide vane was higher than that of the traditional cylindrical guide vane at the same operating conditions. This work confirms the feasibility of predict the pump performance by numerical simulation, and provides the reference for the improvement of the guide vane performance.