Abstract: In order to improve the solubility of compound egg powder, egg powder with high Fe content was prepared by spray-drying technology, using egg as a raw material and ferrous sulfate as nutrition additive of Fe. The effects of the flow rate of spray, introduction temperature and inlet air temperature on the solubility of Fe enrichment egg powder were investigated by second general combination of rotating design method, and the regression model between the solubility of Fe enrichment egg powder and each factor was obtained. The results showed that: the flow rate of spray and inlet air temperature had significant influence on the solubility of Fe enrichment egg powder (p<0.05). The sequence of influence from significant to common was the flow rate of spray, inlet air temperature and introduction temperature. The optimum parameters were the flow rate of spray 22?mL/min, introduction temperature 39.82℃, inlet air temperature 178.21℃. With the optimum condition, the solubility exponent of production was 1.87, water holding capacity 5.63 mL/g, agglomeration 24.58?g/100g and comprehend score was 110.18. Comparing the nutritional compositions of fresh egg, the content of Fe in Fe enrichment egg powder was 77.67%. Thus it can be concluded that it is possible to improve the solubility of Fe enrichment egg powder with the technology of spray drying.