Abstract: Comprehensive utilization of wheat germ (WG) has a great practical significance in relieving widespread shortage of protein and lipid resource, and raising the level of dietary nutrition and health of Chinese people. Firstly, the paper elaborates the exploitation status, resource distribution, quality difference and the existing problems of wheat germ exploitation in China. Then, the latest technology progress home and abroad is introduced in detail, including wheat germ efficient separation, stabilization, oil extraction, microbial fermentation of wheat germ, etc. Ultimately an integrated program is put forward, including the core extracting system of high purity wheat germ, on-line microwave stabilization of wheat germ, sub-critical fluid extraction of wheat germ oil, fermentative wheat germ meal for further preparation of anti-tumor function foods. The research is prospected to provide benificial reference for flour enterprises in better exploiting wheat germ resources.