Abstract: Greenhouse horticulture developed very quickly in China, and it has been an important model of high production and high economic return of agriculture. But with the more than 30 years practice of greenhuose cultivation, some serious ecological problems emerged, including soil secondary salinization, unbalance of N, P, K nutrient, obstacles of continuous cropping, exceeding criterion of nitrate content and so on. According to these problems, the clean production strategy was put forward, such as applying fertilizer scientifically and balanced according to the soil fertility and crop requirement, adopting high efficient water resource utilization technique e.g. drip irrigation of nutrient liquid, using rotation, grafting and organic substrate soilless culture technique to prevent continuous cropping obstacle, and to adopt integrating management technology of combining agronomic, physical and chemical method to prevent and cure plant disease and pest insect.