Abstract: In order to improve the stability and efficiency of high pressure equipment, and promote the industrialization of high pressure technology in food production, the design principle of commercial high hydrostatic pressure equipment for food processing, and its structural characteristics and major technical difficulties were proposed. The structure and the optimum parameters of two-way high pressure intensifier, vessel plug, direct-pushing sealing system and large high pressure processing chamber were studied. The total chamber volume of the equipment was 400 L with 100 L of one chamber. The maximum working pressure was 600 MPa and the processing capacity was 1.68 t/h. The results of performance test showed that the system proposed had advantages of steady performance, easy operation and reliable security. Results provide the technical basis for the design and manufacture of large-scale commercial high pressure equipment.