Abstract: Inspection of internal quality through X ray imagery was substantially hindered by the irregularity of agricultural products. A laser system for thickness compensation was built to reduce the effect of uneven thickness on X ray images of meat products. This system was composed of X-ray image acquisition subsystem, laser image acquisition subsystem, mechanical driving system, controlling system and image processing system. The least square method based on the weight function was used to obtain the compensation image, and the establishment of reflection relationship between laser image and thickness mapping image. The X-ray image and laser thickness compensation image of the meat were fused. The OTSU segment algorithm was employed to extract foreign body from the fused image. The experimental results show that the method can eliminate the effects to the meat image caused by uneven thickness with high-efficiency and precision.