Abstract: The valve timing and fuel injection advance angle have enormous influence on the performance of diesel engine. The optimum matching of them is conducive to forming the nicer air-fuel ratio and better combustion efficiency in-cylinder; then the engine can obtain higher power output and lower fuel consumption. To optimize the matching, Firstly, the numerical simulation model of turbocharged direct injection diesel engine was imported into the OPTIMUS, which is a multidisciplinary optimization platform. Then the intake lag angle, exhaust and injection advance angle were regarded as the optimization variables as well as the maximum torque and minimum specific fuel consumption were the optimization objective. After optimization, the mean engine power output has been increased by 2.57%, and the mean specific fuel consumption has been decreased by 2.66%. Finally, the simulation and experimental results show that the design of model is reasonable and accurate, and the overall performance of diesel engine is improved after parameterized optimization.