Abstract: In order to improve winter wheat nitrogen regulation and precision farming at county level，this study selected Anyang county as the study region. Major impacting factors, including terrain, soil type, soil nutrient and spectral data were analyzed and appropriate indices were chosen for the management zone. The zone was executed by cluster analysis and spatial overlay using qualitative and quantitative analyses based on 3S. The results revealed that coefficient variation of soil property and yield were reduced in each level zone. The management zones were the divided 21 subzones under third-level, there were significantly statistical differences between the chemical properties of soil samples in the sub zones. The average coefficients of variation of organic matter; nitrogen and yield reduced 70%, 53% and 66% respectively. The results on zoning can be used as decision-making unit in winter wheat nitrogen regulation and can provide an effective pathway in precision agricultural management.