Abstract: To provide feasible methods for solving region problems, a major function oriented zoning (MFOZ) method based on SLEUTH (slope, land use, exclusive layer, urbanization, transportation, hillshade) was proposed in this paper, which can adjust the MFOZ according to the tendency of land use change. Taking Suzhou-Wuxi region as research object, a typical rapid urbanization area, SLEUTH model was applied to simulate primary regionalization scenarios from 2009 to 2030, describing the land use change after MFOZ. Then ambiguous regions during the first zoning due to fuzzy conditions were adjusted and optimized and complete MFOZ in Suzhou-Wuxi region was obtained. The result showed that this method made MFOZ intuitively predicable and adjustable. Thus this method provides a technical supportive for reasonable implementation of MFOZ.