Abstract: Abstract: Irrigation water-using coefficient played an important technical role in promoting the water-using efficiency and water resources management. Researches of irrigation water-using coefficient are continuously focusing on the single method or other comprehensive theoretical study. However, based on the basic theory, it still existed problems in practical test and application. This paper used the method of the traditional channel test, typical irrigation area water utilization test and 'head to tail' test to study the irrigation comprehensive water-using coefficient in Xinjiang arid region. Traditional method of channel section test was used to get the irrigation water-using coefficient of different kinds of channel (impervious channel or non- impervious channel), and a typical irrigation field selected to detect the water-using coefficient. According to the fundamental information of annual gross water supply volume in irrigation region and net irrigation water supply volume in field area, the irrigation water-using coefficient was also calculated by the 'head to tail' test. Meanwhile, this study analyzed the influential effects of main factors in irrigation region to irrigation water-using coefficient using the Cobb-Douglas model. And the results showed that under the five modes of water diversion canal, water-filling well irrigation, sprinkler irrigation, micro irrigation and low pressure pipeline, the irrigation water-using coefficient are respectively as 0.370,0.687,0.795,0.860,0.800. And then under the previously mentioned five modes, the comprehensive irrigation water-using coefficient in 2011 are respectively showed as 0.498, 0.479, 0.682, 0.581. The comprehensive irrigation water-using coefficient of previously mentioned five modes in 2011 are respectively showed as 0.498, 0.479, 0.682 and 0.581 in Xinjiang irrigation region, Southern, Eastern, and Northern Xinjiang irrigation regions. Based on the Cobb-Douglas model, the result indicated that the anti-seepage, well irrigation and high efficient water-saving agriculture construction contributed significantly to enhance the comprehensive irrigation water-using coefficient. This research can provide a technical basis to control the water-using efficiency and total water resources in Xinjiang arid region.