Abstract: Taking Haiyan county in Zhejiang Province being located in the Yangtze River Delta as an instance, the spatial change patterns of land use in 1995 and 2000 were simulated respectively with applying the CLUE-S model by using the spatial data of land use in 1986 and the driving factors affected land use change. The simulations coincide with the realities. Then, the spatial change patterns of land use in future 20 years were simulated three times by using the model. Results show that the areas around the county town and main towns and along the main highways are the main cultivated land non-agriculturalization areas. The delimitation of basic farmland protection area is important to the protection of cultivated land.