Abstract: Simulation of distribution of agricultural output value is a basis of objective assessment of production efficiency of agriculture and of making policy of the development of agriculture. According to the different relationships of altitude and output value of agriculture, counties of Tibet were plotted off two patterns, and the relationships between output value of agriculture and land use, topographical indices were analyzed by integrating geo-statistics method and spatial analysis function of geographic information system(GIS). Taking land use as indicator factors, considering the effects of topographical indices on spatial distribution of agriculture output value, the simulation model of distribution of agriculture output value were established based on fusing multiple source data by multiplication. Results show that the relative error of 8 testing samples in total 12 is lower than 30%, so the result is reliable. Furthermore, the simulation results reflect the distribution of agriculture output value in Tibet objectively: the development of agriculture in Tibet is very low, and there is more than 80% of Tibetan land in which output value of agriculture is lower than 5400 RMB/km², and the agriculture output value in Yarlung Zangbo Jiang, Lhasa he and Nyang Qu drainage area and Qamdo Diqu is higher than that of other region. So the simulation of distribution model is helpful to recognize agricultural development level of Tibet and has profound implications for regional sustainable development.