Abstract: Using straight sugarcane and bending sugarcane as subject investigated, an indoor simulative experiment of sugarcane detrashing was carried out on the main factors which affected the detrashing quality, by means of the quadratic general rotary unitized design, statistical analysis and computer optimization technique. And the corresponding mathematical model was established. The influence law and mechanism of the factors and their interaction on the detrashing quality were analyzed, and the respective optimization combination of main factors was gained. The results indicated that the influence law of experimental factors on the detrashing quality of the straight and bending sugarcane had large difference. The combined optimization results of experimental factors increased the detrashing quality effectively, and the impurity rate and rupture rate of straight sugarcane is 0～0.78% and 0～8.43%, the impurity rate and rupture rate of bending sugarcane is 0～0.5% and 0～18%.